1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile - Names and Identifiers

Name	1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile
Synonyms	EOS-61660 1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile (E)-tert-Butyl 5-(3-methoxy-3-oxoprop-1-en-1-yl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
CAS	1234616-67-1
InChIKey	UEWIETUNZIVFLI-UHFFFAOYSA-N

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile - Physico-chemical Properties

Molecular Formula	C7H4N4
Molar Mass	144.13
Density	1.44±0.1 g/cm3(Predicted)
Boling Point	397.1±22.0 °C(Predicted)
pKa	8.11±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Sensitive	Irritant
MDL	MFCD17015872

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile - Introduction

5-Cyano-1H-pyrazolo [3,4-b] pyridine, also known as Zebularine pyrazole, is an organic compound. Its chemical formula is C9H6N2O and has the structure of one pyrazole ring and one pyridine ring. The following is a description of the properties, uses, preparation and safety information of 5-cyano-1H-pyrazolo [3,4-b] pyridine:

Nature:
-Appearance: White to light yellow crystalline powder.
-Melting point: about 207-209°C.
-Solubility: Soluble in polar solvents such as water and alcohol, slightly soluble in non-polar solvents such as petroleum ether.
-Stability: Stable at room temperature.

Use:
-Anti-tumor activity: 5-cyano-1H-pyrazolo [3,4-b] pyridine has the activity of inhibiting DNA methyltransferase and can inhibit the growth and spread of tumors, so it has potential application value in anti-tumor research.
-Antiviral activity: Studies have shown that 5-cyano-1H-pyrazolo [3,4-b] pyridine can inhibit the growth and replication of specific viruses (such as HIV and hepatitis B virus).

Preparation Method:
-5-cyano-1H-pyrazolo [3,4-b] pyridine can be prepared by a synthetic route, which mainly includes cyanation with appropriate starting materials and structural modification through reaction steps such as acetylation and acylation.

Safety Information:
-Under the conditions of correct use and storage, 5-cyano-1H-pyrazolo [3,4-b] pyridine has less impact on human health.
-it has a certain irritation, need to pay attention to avoid inhalation of dust or contact with skin and eyes.
-Observe relevant safety procedures and personal protective measures during handling, storage and handling.

Please note that due to the relatively new application of 5-cyano-1H-pyrazolo [3,4-b] pyridine in the field of medical research, some information may still need further research and verification. Before use, refer to the relevant scientific literature and safety guidelines.

Last Update：2024-04-09 20:49:11